March 3, 2022
7:45 AM - 4:45 PM
In Conjuntion with the 2022 Radiosurgery Society® Scientific Meeting
Omni La Costa, Carlsbad, CA
The symposium will focus on the proposed mechanisms of action and strategies for clinical translation of the novel, unconventional spatial-fractionated and dose-rate modification modalities of GRID, LATTICE and FLASH radiotherapy. Clinical translation sections will focus on developing a consensus approach to clinical utilization and for clinical trial design. A practical planning workshop will be included to walk both inexperienced and experienced users of these modalities through the clinical and physics considerations of delivering these modalities. Mechanisms for synergism of these techniques with other modalities such as immunotherapy, conventionally fractionated radiotherapy, and proton therapy will be discussed.
7:45 - 8:00 AM | Opening Remarks - "Emerging Modalities" |
C. Norman Coleman, MD, Radiation Research Program, National Cancer Institute, National Institutes of Health, and
Mansoor Ahmed, PhD, Radiation Research Program, National Cancer Institute, National Institutes of Health | |
8:00 - 9:15 AM | GRID Therapy |
Moderators: James (JW) Snider, MD, Associate Professor, Dept. of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL SESSION OBJECTIVES | |
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8:00 - 8:15 | Peaks and Valleys: What May or May Not be Important for the Successful Use of the Biological Response to Spatially Fractionated Radiotherapy Robert J. Griffin, PhD, University of Arkansas, AR |
8:15 - 8:30 | Spatially Fractionated (GRID) Radiotherapy for High-Risk Soft Tissue Sarcoma: An Illustrative, Initial Clinical Experience J.W. Snider, MD, University of Alabama at Birmingham, AL |
8:30 - 8:45 | GRID Physics Hualin Zhang, PhD, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, IL |
8:45 - 9:00 | Clinical Trials in GRID Radiotherapy Majid Mohiuddin, Northwestern Chicago Proton Center and Lutheran General Hospital, IL |
9:00 - 9:15 | Open Forum/Question & Answer Session |
9:15 - 10:30 AM | LATTICE Therapy |
Moderators: Majid Mohiuddin, MD, Northwestern Chicago Proton Center and Lutheran General Hospital, IL, and J.W. Snider, MD, University of Alabama at Birmingham, AL SESSION OBJECTIVES | |
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9:15 - 9:30 | GRID to LATTICE: More Tools in the Toolbox Byong Yong Yi, PhD, University of Maryland, MD |
9:30 - 9:45 | Clinical Applications of LATTICE: The Innovative Cancer Institute Experience Beatriz Amendola, MD, Innovative Cancer Institute, FL |
9:45 - 10:00 | Clinical Exploitation of Bystander Effect in Treatment of Large Tumors using Carbon-Ions: High-Dose Partial Tumor Irradiation Tubin Slavisa, MD, MedAustro Center for Ion Therapy and Research, Austria |
10:00 - 10:15 | Practical Clinical Trials in LATTICE Radiation Anand Mahadevan, MD, Geisinger Health, PA |
10:15 - 10:30 | Open Forum/Question & Answer Session |
10:30 - 11:45 AM | FLASH Therapy |
Moderators: J.W. Snider, MD, University of Alabama at Birmingham, AL, and
Arpit Chhabra, MD, New York Proton Center, NY SESSION OBJECTIVES | |
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10:30 - 10:45 | The Evolving Saga of FLASH Radiotherapy: An Effective Treatment against Glioblastoma that Minimizes Neurocognitive Side Effects Charlie Limoli, PhD, University of California, Irvine, CA |
10:45 - 11:15 | Emerging Clinical Trial Concepts in FLASH Therapy Charles B. Simone, II, MD, FACRO, New York Proton Center and Memorial Sloan Kettering Cancer Center, NY |
11:15 - 11:45 | Practical Aspects for FLASH Therapy Charles B. Simone, II, MD, FACRO, New York Proton Center and Memorial Sloan Kettering Cancer Center, NY, and Minglei Kang, PhD, New York Proton Center, NY |
11:45 - 12:00 | Open Forum/Question & Answer Session |
Noon - 1:30 PM | Varian Hosted Lunch with FLASH Presentation ![]() |
12:15 - 12:45 | Latest Updates on FLASH. Translation from Biology to Clinic Deepak "Dee" Khuntia, MD, FASTRO Senior Vice-President, Medical Affairs and Chief Medical Officer |
12:45 - 1:15 | Discussion/Question & Answer Session |
1:15 - 1:30 | Break |
1:30 - 2:30 PM | Proton GRID/LATTICE Therapy |
Moderators: James (JW) Snider, MD, Associate Professor, Dept. of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, and
Charles B. Simone, II, MD, FACRO, Professor and Chief Medical Officer, New York Proton Center and Memorial Sloan Kettering Cancer Center, New York, NY SESSION OBJECTIVES | |
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1:30 - 1:45 | Clinical Utilization of Proton GRID (Beamlets) Jason Molitoris, MD, University of Maryland, MD |
1:45 - 2:00 | Emerging Techniques in Proton GRID/LATTICE Arpit Chhabra, MD, New York Proton Center, NY |
2:00 - 2:15 | Physics Considerations in Proton GRID/LATTICE Sina Mossahebi, PhD, University of Maryland School of Medicine, MD |
2:15 - 2:30 | Open Forum/Question & Answer Session |
2:30 - 4:00 PM | Practical Aspects of GRID and Lattice Treatment Planning & Delivery |
Moderator: James (JW) Snider, MD, Associate Professor, Dept. of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL SESSION OBJECTIVES | |
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2:30 - 3:00 | Practical Aspects for GRID Therapy Jason Molitoris, MD, university of Maryland, MD |
3:00 - 3:30 | Practical Aspects for LATTICE Therapy Beatriz Amendola, MD, Innovative Cancer Institute, FL, and Naipy Perez, MS, Innovative Cancer Institute, FL |
3:30 - 4:00 | Practical Aspects for Proton GRID Therapy J.W. Snider, MD, University of Alabama at Birmingham, AL, and Sina Mossahebi, PhD, University of Maryland School of Medicine, MD |
4:00 - 4:30 | Open Forum/Question & Answer Session/Next Steps |
4:30 - 4:45 PM | Closing Remarks |
Charles B. Simone, II, MD, FACRO, Professor and Chief Medical Officer, New York Proton Center and Memorial Sloan Kettering Cancer Center, New York, NY | |