2022 SYMPOSIUM

2022 Symposium

Advancements in GRID, Lattice and FLASH Radiotherapy Symposium

March 3, 2022 7:45 AM - 4:45 PM
In Conjuntion with the 2022 Radiosurgery Society® Scientific Meeting
Omni La Costa, Carlsbad, CA

The symposium will focus on the proposed mechanisms of action and strategies for clinical translation of the novel unconventional spatial-fractionated and dose-rate modification modalities of GRID, Lattice and FLASH radiotherapy. Clinical translation sections will focus on developing a consensus approach to clinical utilization and for clinical trial design. A practical planning workshop will be included to walk both inexperienced and experienced users of these modalities through the clinical and physics considerations of delivering these modalities. Mechanisms for synergism of these techniques with other modalities such as immunotherapy, conventionally fractionated radiotherapy, and proton therapy will be discussed.

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Target Audience: Radiation oncologists, medical physicists, cancer biologists, radiation biologists, medical oncologists and surgical oncologists.

Symposium Objectives
  • Provide a forum for experts and the established working groups on GRID, Lattice and FLASH radiotherapy to share most current knowledge and new scientific results.
  • Define challenges of GRID, Lattice and FLASH radiotherapy for clinical translation aimed at improving radiation delivery and clinical care.
  • Develop clinical studies using GRID, Lattice and FLASH radiotherapy for the treatment of cancer.

Organizing Committee

  • Soren Bentzen, PhD, Professor of Radiation Oncology, Dept. of Radiation Oncology, University of Maryland, Maryland, MD
  • Robert J. Griffin, PhD, Professor and Director, Radiation Biology Division, University of Arkansas for Medical Sciences, Dept. of Radiation Oncology, Little Rock, AR
  • Charlie Limoli, PhD, Professor, Vice Chair of Research and Academic Affairs, Dept. of Radiation Oncology, University of California, Irvine, CA
  • Nina Mayr, MD, FASTRO, FAAAS, Professor of Radiation Oncology, University of Washington, Seattle, WA
  • Majid Mohiuddin, MD, Medical Director, Radiation Oncologist, Northwestern Chicago Proton Center and Lutheran General Hospital, Parkridge, IL
  • Charles B. Simone, II, MD, FACRO, Professor and Chief Medical Officer, New York Proton Center and Memorial Sloan Kettering Cancer Center, New York, NY
  • James (JW) Snider, MD, Associate Professor, Dept. of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL
  • Xiaodong Wu, PhD, Founder & President Medical Physics Associates and Biophysics Research Institute of America, Adjunct Professor, Department of Biomedical Engineering, University of Miami, Miami, FL
  • Hualin Zhang, PhD, Associate Professor, Dept. of Radiation Oncology, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, IL

AGENDA


7:45 - 8:00 AM

Opening Remarks - "Emerging Modalities"

C. Norman Coleman, MD, Radiation Research Program, National Cancer Institute, National Institutes of Health, and
Mansoor Ahmed, PhD, Radiation Research Program, National Cancer Institute, National Institutes of Health


8:00 - 9:15 AM

GRID Therapy

Moderators: Xiaodong Wu, PhD, University of Miami, FL, and
Samuel Marcrom, MD, University of Alabama at Birmingham, AL

SESSION OBJECTIVES

  • To summarize clinical utilization and evaluate clinical outcomes to date with GRID Therapy
  • To evaluate radiobiologic rationale and effects of GRID Therapy
  • To detail the physics considerations/challenges in delivery and quality assurance around GRID Therapy
8:00 - 8:15Peaks and Valleys: What May or May Not be Important for the Successful Use of the Biological Response
to Spatially Fractionated Radiotherapy
Robert J. Griffin, PhD, University of Arkansas, AR
8:15 - 8:30Spatially Fractionated (GRID) Radiotherapy for High-Risk Soft Tissue Sarcoma: An Illustrative, Initial Clinical Experience
J.W. Snider, MD, University of Alabama at Birmingham, AL
8:30 - 8:45GRID Physics
Hualin Zhang, PhD, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, IL
8:45 - 9:00Clinical Trials in GRID Radiotherapy
Majid Mohiuddin, Northwestern Chicago Proton Center and Lutheran General Hospital, IL
9:00 - 9:15Open Forum/Question and Answer Session


9:15 - 10:30 AM

Lattice Therapy

Moderators: Majid Mohiuddin, MD, Northwestern Chicago Proton Center and Lutheran General Hospital, IL, and
J.W. Snider, MD, University of Alabama at Birmingham, AL

SESSION OBJECTIVES

  • To summarize clinical utilization and evaluate clinical outcomes to date with Lattice Therapy
  • To evaluate radiobiologic rationale and effects of Lattice Therapy
  • To detail the physics considerations/challenges in delivery and quality assurance around Lattice Therapy
9:15 - 9:30GRID to Lattice: More Tools in the Toolbox
Byongyong Yi, PhD, University of Maryland, MD
9:30 - 9:45Modeling Biological Effects for SFRT
Xiaodong Wu, PhD, University of Miami, FL
9:45 - 10:00Clinical Applications of Lattice: The Innovative Cancer Institute Experience
Beatriz Amendola, MD, Innovative Cancer Institute, FL
10:00 - 10:15Practical Clinical Trials in Lattice Radiation
Anand Mahadevan, MD, Geisinger Health, PA
10:15 - 10:30Open Forum/Question and Answer Session


10:30 AM - Noon

FLASH Therapy

Moderators: J.W. Snider, MD, University of Alabama at Birmingham, AL, and
Arpit Chhabra, MD, New York Proton Center, NY

SESSION OBJECTIVES

  • To summarize clinical utilization and evaluate clinical trials/clinical trial designs to date with FLASH Therapy
  • To evaluate radiobiologic rationale and effects of FLASH Therapy
  • To detail the physics considerations/challenges in delivery and quality assurance around FLASH Therapy
  • To demonstrate clinical principles and practical planning tips for FLASH Therapy
10:30 - 10:45The Evolving Saga of FLASH Radiotherapy: An Effective Treatment against Glioblastoma
that Minimizes Neurocognitive Side Effects
Charlie Limoli, PhD, University of Irvine, CA, and
Marie-Catherine Vozenin, PhD, HDR, University of Lausanne, France
10:45 - 11:15Emerging Clinical Trial Concepts in FLASH Therapy
Charles B. Simone, II, MD, New York Proton Center, NY
11:15 - 11:45Practical Aspects for FLASH Therapy
Charles B. Simone, II, MD, New York Proton Center and Memorial Sloan Kettering Cancer Center, NY, and
Minglei Kang, PhD, New York Proton Center, NY
11:45 - 12:00Open Forum/Question and Answer Session


12:00 - 1:30 PM


Varian Hosted Lunch 


1:30 - 2:30 PM

Proton GRID/Lattice Therapy

Moderators: Xiaodong Wu, PhD, University of Miami, FL, and
Samuel Marcrom, MD, University of Alabama at Birmingham, AL

SESSION OBJECTIVES

  • To summarize clinical utilization and evaluate clinical outcomes to date with Proton GRID Therapy
  • To evaluate radiobiologic rationale and effects of Proton GRID Therapy
  • To detail the physics considerations/challenges in delivery and quality assurance around Proton GRID Therapy
1:30 - 1:45Clinical Utilization of Proton GRID (Beamlets)
Jason Molitoris, MD, University of Maryland, MD
1:45 - 2:00Emerging Techniques in Proton GRID/Lattice
Arpit Chhabra, MD, New York Proton Center, NY
2:00 - 2:15Physics Considerations in Proton GRID/Lattice
Sina Mossahebi, PhD, University of Maryland School of Medicine, MD
2:15 - 2:30Open Forum/Question and Answer Session


2:30 - 4:30 PM

Practical Aspects of GRID and Lattice Treatment Planning & Delivery


SESSION OBJECTIVES

  • To demonstrate clinical principles and practical planning tips for GRID Therapy
  • To demonstrate clinical principles and practical planning tips for Lattice Therapy
  • To demonstrate clinical principles and practical planning tips for Proton GRID Therapy
2:30 - 3:00Practical Aspects for GRID Therapy
William Regine, MD, University of Maryland, MD
3:00 - 3:30Practical Aspects for Lattice Therapy
Beatriz Amendola, MD, Innovative Cancer Institute, FL, and
Xiaodong Wu, PhD, University of Miami, FL
3:30 - 4:00Practical Aspects for Proton GRID Therapy
J.W. Snider, MD, University of Alabama at Birmingham, AL, and
Sina Mossahebi, PhD, University of Maryland School of Medicine, MD
4:00 - 4:30Open Forum/Question and Answer Session/Next Steps


4:30 - 4:45 PM

Closing Remarks

Nina Mayr, MD, FASTRO, FAAAS, University of Washington, WA


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Registration Rates

  • $99.00 - Symposium Only, Non-RSS Member
  • $59.00 - Symposium Only, RSS Member
  • $59.00 - Symposium with 2022 RSS Scientific Meeting Registration


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