CLINICAL TRIALS

Clinical Trials


Consensus Guidelines for Clinical Trial Design

The Radiosurgery Society® (RSS) supports collaborative groups and individuals to develop and share clinical and research protocols for stereotactic radiosurgery (SRS), stereotactic body radiation therapy (SBRT) and emerging advanced therapy modalities.

The Consensus Guidelines for Clinical Trial Design is a new platform for expert groups to post consensus concepts on proposed clinical trial recommendations and solicit review and feedback from the medical, physics and science community through the RSS Public Comment Survey. The goal of the Consensus Guidelines for Clinical Trial Design is to encourage the development of clinical trials in SRS/SBRT and advanced radiation therapy modalities through common understanding and consensus on the design elements of clinical trials.

New Publication

An International Consensus on the Design of Prospective Clinical–Translational Trials in Spatially Fractionated Radiation Therapy


Congratulations to The RSS GRID, LATTICE, Microbeam and FLASH Radiotherapy Working Groups on their recent publication in Advances in Radiation Oncology, Volume 7, Issue 2, 100866, March 01, 2022.

Read It Here

Consensus Guideline Projects

SFRT for Gynecologic Cancer

Consensus Guideline for the Design of Clinical Trials in Spatially Fractionated Radiation Therapy for Gynecologic Cancer

Spatially fractionated radiation therapy (SFRT) using GRID and LATTICE therapy, the treatment of tumors with a highly non-uniform dose, has shown much promise in early clinical studies for improving tumor control and reducing side effects in bulky advanced cancers. However, prospective multi-institutional clinical trials to investigate this technique further are needed.

The RSS GRID, LATTICE, Microbeam and FLASH Radiotherapy Working Groups have established an SFRT Clinical Trial Design Consensus effort to help encourage and streamline the development of clinical trials in SFRT for specific tumors. Download an overview of the consensus guideline development process.

The Consensus Guideline for the Design Clinical Trials in SFRT for Gynecologic Cancer has been developed by an Expert Panel of the Working Groups. 

The Public Comment Period on the Clinical Trial Design in SFRT for Gynecologic Cancer is now closed. Thank you to those who participated.

    SFRT for Lung Cancer

    Consensus Guideline for the Design of Clinical Trials in Spatially Fractionated Radiation Therapy for Lung Cancer

    Spatially fractionated radiation therapy (SFRT) using GRID and LATTICE therapy, a form of radiation therapy that uses highly non-uniform doses for the treatment of tumors, has shown much promise in early clinical studies for improving tumor control and reducing side effects in bulky advanced cancers. However, prospective multi-institutional clinical trials to investigate this technique further are needed.

    The RSS GRID, LATTICE, Microbeam and FLASH Radiotherapy Working Groups have established an SFRT Clinical Trial Design Consensus effort to help encourage and streamline the development of clinical trials in SFRT for specific tumors.

    A Consensus Guideline for Clinical Trial Design in SFRT for Lung Cancer has been developed by an expert panel of the GRID, LATTICE, Microbeam and FLASH Radiotherapy Working Groups. 

    The Public Comment Period on the Clinical Trial Design in SFRT for Lung Cancer is closed now.  Thank you to those who participated.

    SFRT for
    Sarcoma

    Consensus Guideline for the Design of Clinical Trials in Spatially Fractionated Radiation Therapy for Sarcoma

    Spatially fractionated radiation therapy (SFRT) using GRID and LATTICE therapy, a form of radiation therapy that uses highly non-uniform doses for the treatment of tumors, has shown much promise in early clinical studies for improving tumor control and reducing side effects in bulky advanced cancers. However, prospective multi-institutional clinical trials to investigate this technique further are needed.

    The RSS GRID, LATTICE, Microbeam and FLASH Radiotherapy Working Groups have established an SFRT Clinical Trial Design Consensus effort to help encourage and streamline the development of clinical trials in SFRT for specific tumors. 

    The Consensus Guideline for Clinical Trial Design in SFRT for Sarcoma has been developed by an expert panel of the Working Groups.

    The Public Comment Period is now closed. Thank you to those who participated.

    SFRT for
    Head & Neck
    Cancer

    Consensus Guideline for the Design of Clinical Trials in Spatially Fractionated Radiation Therapy for Head and Neck Cancer

    Spatially fractionated radiation therapy (SFRT) using GRID and LATTICE therapy, a form of radiation therapy that uses highly non-uniform doses for the treatment of tumors, has shown much promise in early clinical studies for improving tumor control and reducing side effects in bulky advanced cancers. However, prospective multi-institutional clinical trials to investigate this technique further are needed.

    The RSS GRID, LATTICE, Microbeam and FLASH Radiotherapy Working Groups have established an SFRT Clinical Trial Design Consensus effort to help encourage and streamline the development of clinical trials in SFRT for specific tumors. Read about the guideline development process.

    The Consensus Guideline for Clinical Trial Design in SFRT for Head and Neck Cancer has been developed by an expert panel of the Working Groups.

    The Public Comment Period is now closed. Thank you to those who participated.

    Would you like to be involved?