In the upcoming webinar, we will discuss: Guidelines for the treatment of non-metastatic anal cancer include the use of Intensity-modulated Radiotherapy (IMRT) or Volumetric Modulated Radiotherapy (VMAT) in association with chemotherapy. The use of highly conformal treatment of anal cancer- This is attractive because of the large treatment volumes adjacent to the small bowel and bladder as well as exposure of the skin in the gluteal fold to high doses. The excellent oncological outcomes of radio-chemotherapy in anal cancers are historically associated with related side effects: hematologic toxicity, skin reaction, gastrointestinal and genitourinary toxicity. The advantage of the TomoTherapy® System compared to the VMAT technique with a homogeneous Planning Target Volume (PTV) coverage, a simultaneous integrated boost (SIB) approach if indicated, and a daily Megavoltage CT imaging as part of image-guided radiotherapy (IGRT) to allow for bony and soft tissue alignment.